Dementia is a progressive condition, meaning that it gets worse over time. The speed of deterioration differs between individuals. Age, general health and the underlying disease causing brain damage will all affect the pattern of progression. However, for some people the decline can be sudden and rapid.

The deterioration of dementia is usually slow and gradual. Rapidly progressive dementias or RPDs are different. They progress quickly, frequently over a period of weeks or months, and can swiftly prove fatal. Rapidly progressive dementias are rare, but they can be very distressing for the individual affected and for those that love and care for them.

Why might dementia progress quickly?

Alzheimer’s disease typically has a slow and gradual progression, whereas people affected by vascular dementia tend to show periodic, step-wise impairments in function. However, many factors have an impact on the development of dementia. An individual’s genetic heritage will play a role, as does their general, physical health. People with cardiovascular disease or diabetes, especially if they are poorly controlled, are at risk of a faster deterioration. People who are frail with low immunity and recurrent infections are also vulnerable. Young-onset dementia tends to progress more rapidly, and people who develop dementia between the ages of thirty and fifty, appear to live two years less than those whose dementia is diagnosed later in life.

Most cases of sudden confusion and rapidly progressive dementia in an elderly person are due to delirium caused by infection. Urinary infections and pneumonia can trigger acute confusion that comes on quickly, causing people to be incoherent, muddled and disorientated. Agitation, aggression and odd behaviour are also common. The good news is that the symptoms of delirium can be reversed when the infection is appropriately treated.

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Could it be rapidly progressive dementia?

RPD can be difficult to diagnose, however, accurately diagnosing these conditions is critical in order to identify any treatable causes and protect against further brain cell damage. An early hospital assessment by a specialist can help pick up problems so that, where available, appropriate treatment can be initiated. Cancers, infections, toxins and autoimmune conditions could all cause a fast decline in mental function, as well as the more common neurodegenerative causes of dementia such as Alzheimer’s, strokes and Parkinson’s disease.

Investigation of RPD

In an assessment for RPD, the doctor will take a detailed history to find out about the symptoms and challenges that the person is facing. Enquiring about past medical history, the health of close family and any recent exposure to chemicals, infections or medications can help pinpoint any potential causes. A careful examination can help the doctor spot any physical problems and evaluate the current level of mental function.

Investigations will typically include laboratory tests of blood, urine and the fluid surrounding the brain and spinal cord. The brain will be scanned using an MRI or CT device and an electroencephalogram, or EEG, to measure electrical activity in the brain may be performed. All of this information will assimilate and considered to help diagnose the cause of the dementia.

What happens in rapidly progressive dementia?

The presentation and progress of RPD will vary between individuals. People affected will usually develop problems with their memory, thought processes and communication. Many people also have personality or behavioural changes and mood disturbance. Movement changes can also occur as a result of the brain cell injury.

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Some forms of RPD are treatable and, if diagnosis is made quickly, early symptoms may be reversed. Regrettably, for other causes of the condition, there are no available cures. There is an inevitable increase in symptoms and decline in function. Sadly, within months or years, the rapidly progressive dementia will cause failure of all body systems and death.

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What causes RPD?

There are many causes of RPD, these include:

  • Auto-immune diseases
  • Unusual presentations of common causes of dementia
  • Hormonal disturbances and metabolic disorders
  • Prion diseases
  • Infections
  • Disturbed blood flow to the brain
  • Structural problems of the brain
  • Toxins
  • Vitamin deficiencies
  • Cancer
  • Side effects or complications from prescribed medications
  • Recurrent fits or seizures

What is the treatment of Rapid Progressive Dementia?

The right treatment for RPD will depend on the type of dementia and the cause of the condition. For RPD caused by cancer, hormone imbalance or metabolic disturbances, treatment to that target the underlying cause may help treat the dementia too. Unfortunately, for many people no cure is available, however treatment may help reduce distress, maintain comfort and improve quality of life.


Dr Jane Gilbert

Jane has over 20 years’ experience as a health writer and TV presenter. Jane writes on a wide variety of clinical and care topics – from explaining the latest studies and research to unpacking conditions and discussing treatment options. Jane holds a MBBS degree from Imperial College, London and spent seven years working in the NHS.

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